10,000 Bullets follows Crow, a hitman living in Ireland who works for the Rome-based crime syndicate known as the Tonia Family. Crow possesses the special "gunslinger" ability, which allows him to slow down time. He inherited this trait from his late mother, a powerful fortune teller who was murdered when Crow was very young. After being taken in by mob boss Papa Tonia, Crow is taught to optimize his abilities by a fellow hitman named Judas, a fugitive from France. Crow hopes to one day exact revenge on the person responsible for his mother's death.